Fatal familial insomnia (FFI) is a very rare autosomal dominant inherited prion disease of the brain. It is almost always caused by a mutation to the protein PrPC, but can also develop spontaneously in patients with a non-inherited mutation variant called sporadic fatal insomnia (sFI). FFI has no known cure and involves progressively worsening ins...
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http://en.wikipedia.org/wiki/Fatal_familial_insomnia
Type: Term Definitions: 1. [MIM*600072] an autosomal dominant progressive neuropathy with progressive insomnia and thalamic lesions.
Found on
http://www.medilexicon.com/medicaldictionary.php?t=44839
Fatal familial insomnia: Abbreviated FFI. An hereditary prion disease characterized by disrupted sleep (insomnia), motor abnormalities (myoclonus, ataxia, dysarthria, dysphagia, and pyramidal signs), and hyperactivation of the autonomic nervous system. Due to a missense mutation at codon 178 of the prion protein gene on chromosome 20. A sporadic fo...
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http://www.medterms.com/script/main/art.asp?articlekey=22516
No exact match found.
